Antiangiogenic nanotherapy with lipase-labileSn-2fumagillin prodrug
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چکیده
منابع مشابه
Fumagillin Prodrug Nanotherapy Suppresses Macrophage Inflammatory Response via Endothelial Nitric Oxide
Antiangiogenesis has been extensively explored for the treatment of a variety of cancers and certain inflammatory processes. Fumagillin, a mycotoxin produced by Aspergillus fumigatus that binds methionine aminopeptidase 2 (MetAP-2), is a potent antiangiogenic agent. Native fumagillin, however, is poorly soluble and extremely unstable. We have developed a lipase-labile fumagillin prodrug (Fum-PD...
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ژورنال
عنوان ژورنال: Nanomedicine
سال: 2012
ISSN: 1743-5889,1748-6963
DOI: 10.2217/nnm.12.27